Adrenocorticotropic Hormone and body thermoregulation

 

Frank P Russo - 2005-10-30.

 

With the “Immuno-nuclear” Adrenocorticotropic Hormone kit, (the latter henceforth referred to as ACTH), I used to have a reading of just over 700 when most people had a reading of about 25 or somewhere between 0 and 100, and I think the units might have been something like picograms per ml.

Now to my understanding ACTH was always to do with cortisol production and stress. It is however a well known fact that ACTH controls Aldosterone production, with its sodium retention very acutely. Furthermore ACTH is produced from the Proopiomelanocortin, (POMC, 265 Amino Acids), which also yields things such as gamma-melanocyte-stimulating hormone (gamma-MSH). Hence what I came up with, is that ACTH is mainly to do with thermoregulation. When the body is warm or hot, the ACTH level is lower leading to a lower Aldosterone level… this in turn is more conducive to allow enough water to escape via evaporation or urinary excretion, leading to a cooling down of the body. Remember that it is mainly the sodium and albumin that from memory, I think were responsible for the blood’s osmotic pressure thus leading to water retention. The fact that ACTH production is pulsatile is reminiscent of how a fridge thermo-regulates with its thermostat coming on and off! It is also suggestive of how my Sunbeam frying pan’s orange light comes on and off as it keeps the temperature steady!)

Thus the ACTH, MSH and Aldosterone all mesh together, (like a chess combination where ACTH is the ‘Queen’), to control our body’s temperature: mine at about 36.8 Celsius. The MSH absorbs the solar heat throughout the body’s skin via the pigment melanin which it controls. Naturally it brings this heat mainly to the feet relatively speaking, seeing that the feet are usually the coldest parts of the body, sometimes as low as 20 degrees Celsius (usually about 24). At the feet this heat engenders the production of heat-labile ACTH which is the body’s thermostat-equivalent of a car or fridge! In this ACTH production, the chief raw ingredients used are ascorbic acid and cholesterol: the former mainly to provide the reaction electrons, whilst the latter mainly for structural adjustments and this especially so in the hormones which ACTH potentiates to express its biological activity. The interesting thing is that ascorbic acid is heat-labile just like most of my ACTH was, and this is why most of the room-temperature orange juices have a lot of fibre in them: mainly to replicate the stable fruit environment where vitamin C (ascorbic acid), does not go off.

All of the foregoing well illustrates why the ACTH is at its highest at about 4AM, a time when most bodies are at their lowest temperature: this is further accentuated by the fact that the low trough is all over the body as there is usually no “convective-differential” whilst the body is in the horizontal supine position.

In conclusion you might wonder about the magical 37 degrees Celsius: What’s so special about it, when most of the universe is so incredibly cold?! Well the people at the lower level, (where our atoms are universes), with their tiny physiological metres, kilograms, speed of light and their own ‘everything else’ … not only do they have to heat-up a much smaller body than ours (one in ten to the 40), but also for a much shorter duration … their second being one in ten to the 40 of our long seconds … a true relativity! (See my guestbook for a further elaboration of this concept.)

Life is a wonderful privilege and the more knowledge I gain the more I appreciate the Force!

Frank P Russo.

p.s. Of course Vitamin D would fit somewhere in this scheme of things, being a  means of storing light energy and using it... thus preventing disease.

 

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